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ACTIVA Lifesciences

F-10, Shivaji Nagar, Ganesh Galli,, Jangaleshwar Mahadeo Mandir Road, Asalfa Village, Ghatkopar (West),, Mumbai, Maharashtra 400084


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Side effects and Allergic reaction of Azithromycin-250/500 tablets

Allergic reaction

Patients who suffer from an allergic reaction to Azithromycin can experience blood in the stool 4–10 days after ingestion, although cases of this have been recorded as early as after the first day of ingestion.

These allergies are usually non-severe if the treatment is immediately stopped. A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness.

Side effects

Most common side effects are gastrointestinal; diarrhea (5%), nausea (3%), abdominal pain (3%) and vomiting. Fewer than 1% of patients stop taking the drug due to side effects. Serious allergic reactions, nervousness, dermatologic reactions, and fatalities have been reported. As with all antimicrobial agents, pseudomembranous colitis can occur during and up to several weeks after azithromycin therapy. This drug may interfere with the effectiveness of birth control pills; other forms of contraception may be required during the treatment period.

Azithromycin suspension tastes bad, which can make it difficult to administer to young children (e.g. 2 - 5 years) who may spit it out.

Metabolism of Azithromycin-250/500 tablets

Following a single 500 mg dose, plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half-life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues.

Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine.

Pharmacokinetics of Azithromycin-250/500 tablets

Unlike erythromycin, azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed, but its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms and 1 to 2 hours for intravenous (IV) forms.

Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.

Azithromycin's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days.

Mechanism of action and Microbiology of Azithromycin-250/500 tablets

Mechanism of action

Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. Nucleic acid synthesis is not affected.

Microbiology

Azithromycin has a similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Haemophilus influenzae. Azithromycin resistance has been described and is endemic in many areas.

Azithromycin has been most effective against isolates of the following microorganisms:

Staphylococcus aureus

Streptococcus agalactiae

Streptococcus pneumoniae

Streptococcus pyogenes

Haemophilus ducreyi

Haemophilus influenzae

Moraxella catarrhalis

Neisseria gonorrhoeae

Chlamydia pneumoniae

Chlamydia trachomatis

Mycoplasma pneumoniae

Helicobacter pylori

Salmonella typhi

Azithromycin has been shown to be effective against malaria when used in combination with artesunate or quinine; the optimal dose for this is not yet known.

Azithromycin-250 and Azithromycin-500 tablets - Antibiotics and Antibacterials

Azithromycin is an azalide, a subclass of macrolide antibiotics.

Azithromycin is one of the world's best-selling antibiotics, sold in the US under the name Zithromax as well as under generic labels. It is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring, thus making the lactone ring 15-membered.

Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, Typhoid, and sinusitis. In recent years it has primarily been used to prevent bacterial infections in infants and those with weaker immune systems. It is also effective against certain urinary tract infections and venereal diseases, such as non-gonococcal urethritis, chlamydia, gonorrhea and cervicitis. Recent studies have also indicated it to be effective against late-onset asthma, but these findings are controversial and not widely accepted.

Drug interactions and Over-dosage of Rabeprazole

Drug interactions

Rabeprazole decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antacids. Rabeprazole is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin).

Over-dosage

There is no available data on symptoms of rabeprazole overdose.

Contraindications, Restriction of usage and Side effects of Rabeprazole

Contraindications: hypersensitivity to rabeprazole, substituted benzimidazoles or any of components of its pharmaceutical forms.

pregnancy: FDA Pregnancy Ratings: B

lactation: Thomson Lactation Ratings: Infant risk cannot be ruled out.

Restriction of usage: acute hepatic failure

pediatric use in patients under 18 years of age (there are insufficient data about safety and efficiency of rabeprazole in this group of patients)

Side effects:

Rabeprazole adverse reactions/side effects include

• In clinical trials the most common side effect assessed as possibly or probably related to AcipHex was headache in 2.4% of patients vs 1.6% taking placebo.
• diarrhea
• vomiting
• nausea
• abdominal pains
• constipation
• meteorism
• dry mouth
• increased or decreased appetite
• asthenia
• headache
• anxiety
• sleeplessness
• vertigo
• thrombocytopenia
• granulocytopenia
• leukocytopenia
• skin eruption
• erythema
• myalgia
• arthralgia
• muscle or bone pain

Indications and usage of Rabeprazole

Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GERD); maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD; treatment of daytime and nighttime heartburn and other symptoms associated with GERD; long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.

1. Gastric ulcer
2. Peptic ulcer disease (PUD)
3. Maintenance of healing of erosive or ulcerative GERD
4. Healing of erosive and ulcerative GERD
5. Healing of duodenal ulcers.
6. Treatment of symptomatic GERD
7. Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
8. Helicobacter pylori eradication to reduce risk of duodenal ulcer recurrence

What is Rabeprazole?

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.

Rabeprazole is used in

1. Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GERD).
2. maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD.
3. treatment of daytime and nighttime heartburn and other symptoms associated with GERD.
4. long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.

Pharmacology of Pantoprazole

Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation.

Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance.

Pantoprazole is relatively free of drug interactions, however it may alter the absorption of other medications that depend on the amount of acid in the stomach, such as ketoconazole or digoxin.

What is Pantoprazole?

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained.

This medication may affect the results of certain lab tests, such as drug screenings (pantoprazole can cause a false positive for THC). It is recommended you make sure laboratory personnel and your doctor know you are using this drug.

Saffron can prove to be an effective weapon in the fight against sight loss, age-related macular degeneration (AMD) - Health News

The new research indicates that saffron, traditionally used to colour and flavour curries and Mediterranean dishes, can prove to be an effective weapon in the fight against one of the commonest causes of sight loss, age-related macular degeneration (AMD).

The first trials of saffron on human vision shows it significantly enhanced eyesight, reports The Daily Express.

Lead researcher Professor Silvia Bisti said, “When patients were tested with traditional eye charts, a number could read one or two lines smaller than before. Others said they could read newspapers and books again.”

Bisti hailed the results as ‘remarkable’ and claimed saffron “may hold the key to preventing sight loss in the elderly”.

Source: timesofindia.indiatimes.com

Plastic surgeons are reporting a record number of "man boob" reduction operations - Health News

Plastic surgeons are reporting a record number of "man boob" reduction operations as the rise in demand outstrips that for all other procedures, including women's breast enlargement.

Figures published by the British Association of Aesthetic Plastic Surgeons showed operations to correct gynecomastia in men grew by 80%, while overall male cosmetic surgery grew by 21%.

The association's audit reveals 581 male breast reduction operations were performed by members in 2009, up from 323 in 2008. Five years ago, just 22 gynecomastia operations were performed on men. The association represents one in three plastic surgeons, so the UK total is likely to be more than 1,000 operations.

"Probably, heightened media attention … has allowed men to realise the positive outcomes that can be achieved," said Rajiv Grover, the consultant and association secretary who collated the audit.

"There's a lot of pressure on men now to shape up. Men's grooming is on the rise, and big fashion houses are using half-naked men, such a David Beckham, to advertise."

The procedure typically costs £2,000, takes 90 minutes, and removes as much as a litre of fat.

Overall, 36,482 procedures were done by association members for men and women in 2009, compared with 34,187 in 2008, a rise of 6.7%. Women accounted for 32,859, a rise of 5%. The audit reported 8,537 female breast augmentation operations.

Source: www.guardian.co.uk 

Activa Lifesciences is a Mumbai based company looking for PCD and Franchise Stockiest and Distributors

ACTIVA Lifesciences was established in 2007 and since then we are in the manufacturing & marketing of pharmaceuticals. & we have a wide range of formulation, which cover latest products in Tablets, Capsules, Dry Syrups, and Ointments & Granules etc. Lycopene capsules, liquid and many more latest molecule is under process.

We are well known for Quality formulations as well as for prompt services to our customers.

At present we have more than 45 distributors in India.

Profile:

ACTIVA is engaged in the manufacturing of Pharmaceutical Formulations like Tablet, Capsules, Tablet (Beta-Lactum),Capsules (Beta-Lactum), Dry Syrup (Betalactum), Oral Liquids, External Preparations (Creams & Ointments) Our Parent Company is having independent Beta Lactum. Comply all good manufacturing Norms as per REVISED SCHEDULE-M & SCHEDULE-T & holding GMP CERTIFICATE from the food & drugs control administration.

We offer:

Free Catch Covers and Leave Behind Cards

Free Product Cards

Free Visual Aid

And Many More

For Further Details contact us

Wanted PCD and Franchise Distributors and Stockiest from Gujarat State

ACTIVA Lifesciences is in the manufacturing & marketing of pharmaceuticals. & we have a wide range of formulation, which cover latest products in Tablets, Capsules, Dry Syrups, and Ointments & Granules etc. Lycopene capsules, liquid and many more latest molecule is under process.

We are well known for Quality formulations as well as for prompt services to our customers.

At present we have more than 35 distributors in India.

We offer:

1. 10+1 Scheme for All Products
2. Free Catch Covers and Leave Behind Cards
3. Free Product Cards
4. Free Visual Aid
And Many More

For Further Details contact us 

Wanted PCD and Franchise Distributors and Stockiest from Maharashtra

ACTIVA Lifesciences is in the manufacturing and marketing of pharmaceuticals. & we have a wide range of formulation,  which cover latest products in Tablets, Capsules, Dry Syrups, and Ointments and Granules etc. 

Lycopene capsules, liquid and many more latest molecule is under process. 

We are well known for Quality formulations as well as for prompt services to our customers. 

At present we have more than 45 distributors in India.

We offer:

1. 10+1 Scheme for All Products
2. Free Catch Covers and Leave Behind Cards
3. Free Product Cards
4. Free Visual Aid
And Many More

For Further Details contact us